Just months after Grey's Anatomy star Ellen Pompeo revealed she's leaving the show as a series regular, another shake-up has happened on ABC's long-running medical drama, with showrunner Krista Vernoff leaving the show.

Vernoff, 51, who had started as a staff writer on the series when it debuted in 2005, worked her way up to head writer and showrunner of the series.

She was brought back in 2017 to serve as showrunner on both Grey's Anatomy and the spin-off Station 19, but now she's leaving both shows, via Deadline. 

'It has been the privilege of a lifetime to be entrusted to run Grey’s Anatomy for the past six years and Station 19 for the last four,' Vernoff said in a statement.

'The passion of the dedicated fandoms and the impact that these shows have on hearts and minds cannot be overstated,' she added. 

'The amount of talent in these two extraordinary casts and these two brilliant writers rooms is beyond measure — and these crews work magic week after week,' she concluded.

Vernoff was brought back as showrunner ahead of Season 14 in 2017 and has helped lead the show's resurgence in the ratings.

She became the showrunner of Station 19 in 2019, adding multiple crossovers that lead to a resurgence of both shows.

Her first year at the helm of Station 19 saw double-digit increases in the ratings from the previous year, a virtually impossible feat to pull off.

ABC has not officially renewed Grey's for a 20th season yet, and it's currently unconfirmed who will step in for Vernoff, though it's considered a 'safe bet' that the show will be renewed.

Meg Marinis, who started on the show as a researcher in the first season and rose through the ranks to executive producer, is considered to be Vernoff's successor on Grey's.

As for Station 19, Zoanne Clack and Peter Paige are expected to share the duties as co-showrunners.

The news comes just under a month before Pompeo's final episode as a series regular, the mid-season premiere airing February 23.

Her character Meredith Grey will be leaving Seattle, though she is expected to return in the Season 19 finale in May, which will be Vernoff's last episode as well, though she wouldn't count out yet another return down the road.

'The last time I left Grey's Anatomy, I was gone for seven seasons and the show was still going when Shonda called me to run it. So I’m not saying goodbye because that would be too bitter sweet. I’m saying "See you in seven seasons,"' Vernoff said.