Gliomas are malignant brain tumors that originate from glial cells, which do not produce electrical impulses like neurons but instead support neurons by maintaining their structure and function. They are the most common form of brain cancer in adults and hijack normal neuronal signaling, especially the protein neuroligin-3 (NLGN3), released by active nerve cells, to fuel their own growth and spread into healthy brain tissue. Researchers wanted to uncover how NLGN3 interacts with glioma cells and healthy OPCs, and the role it normally plays in healthy brain cells.
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