Tumor Debulking Plus Chemotherapy for Multiorgan Metastatic Colorectal Cancer

Дата публикации: 18-08-2026 00:00:00

To the Editor We welcome the report of the ORCHESTRA randomized clinical trial (RCT) that investigated the effect on overall survival from debulking of metastases after first-line systemic treatment in patients with stage 4 CRC. The trial reported no difference between the 2 groups for the primary outcome of overall survival. PulMiCC, a phase 3 RCT of surgical resection of CRC lung metastases, reached the same conclusion, but, surprisingly, Dr Gootjes and colleagues did not mention it. The editorialist opined that “ORCHESTRA hits a sour note.” We take a contrary view: ORCHESTRA rings true.

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