April 21, 20265:46 AM ET

The ceasefire between the U.S. and Iran expires soon as President Trump calls an extension highly unlikely and Vice President JD Vance heads to Pakistan for talks Iran won't publicly confirm it will attend.
Labor Secretary Lori Chavez-DeRemer resigned amid allegations of an affair with her bodyguard, drinking on the job, and using taxpayer money for personal travel, becoming the third cabinet member to leave in less than two months.
And President Trump's pick to lead the Federal Reserve faces his confirmation hearing today, but Republican Senator Thom Tillis is threatening to block it until the Justice Department drops its investigation of current Fed Chair Jerome Powell.
A previous version of the story "Iran Ceasefire Deadline" incorrectly said the ceasefire between the US, Iran and Israel expires today. It expires on Wednesday.

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Today’s episode of Up First was edited by Ruth Sherlock, Emily Kopp, Rafael Nam, Mohamad ElBardicy, and HJ Mai.

It was produced by Ziad Buchh and Nia Dumas.

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(0:00) Introduction
(01:58) Iran Ceasefire Deadline
(05:59) Labor Secretary Out
(09:33) Hearing For New Fed Chair

There have been conflicting statements as to when the ceasefire expires. On Monday, President Trump told Bloomberg News it ends Wednesday evening Eastern time. Yet mediating country Pakistan's information minister later said it expires Wednesday morning, 4:50 a.m. local time, which would be Tuesday night in Washington.

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