To the Editor We read with interest the recent trial in JAMA Psychiatry of inhaled mebufotenin (GH001) for treatment-resistant depression. Compared with placebo, GH001 showed a significantly greater reduction in depressive symptoms at day 8 and a higher remission rate (23 of 40 patients treated with GH001 [57.5%] vs 0 of 41 patients treated with placebo [0%]).
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