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Спутники
РН
SpaceX
Роскосмос
NASA
СпутникиРНSpaceXРоскосмосNASAChronic kidney disease (CKD) is defined largely by glomerular filtration rate (GFR), a construct with broad clinical implications. Guidelines from Kidney Disease: Improving Global Outcomes categorize CKD stages in adults according to GFR thresholds and albuminuria to assess risk of kidney failure. These CKD categories help clinicians dose medications with a narrow therapeutic window (eg, chemotherapy, antimicrobials), screen for metabolic complications of kidney dysfunction, determine eligibility for kidney transplant, and evaluate risks of death and cardiovascular disease events. Yet a patient’s GFR assessment depends on which test is ordered. In routine clinical practice, GFR is estimated (eGFR) rather than measured (mGFR). Small differences between estimates for GFR that fall close to the thresholds for CKD categorization can reclassify a patient’s disease status, thereby influencing diagnostic testing and treatment decisions. Measured GFR is the reference standard, but it is burdensome, time consuming, and not widely available. Thus, most clinical studies rely on eGFR to determine the associations of CKD with kidney failure, cardiovascular disease, and death.